In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: Tris(dibenzylideneacetone)dipalladium-chloroform, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52522-40-4, name is Tris(dibenzylideneacetone)dipalladium-chloroform. In an article£¬Which mentioned a new discovery about 52522-40-4
Ferrocenyloxazoline-Derived Planar Chiral Palladacycles: C-H Activation, Transmetalation, and Reversal of Diastereoselectivity
Reinvestigation of the palladation of (S)-2-ferrocenyl-4-(methylethyl)oxazoline with Pd(OAc)2 in CH2Cl2 was found to proceed with a dr of 3.6:1 in favor of the resulting S,Sp palladacycle. A similar 4:1 dr was obtained using Na2PdCl4 in MeOH. As an alternative approach, highly diastereoselective lithiation (dr >100:1) and transmetalation were investigated. Addition of PdX2(COD) (X = Cl, Br) to (S,Rp)-2-lithio-1-(2?-(4?-methylethyl)oxazolinyl)ferrocene resulted in double halide substitution and formation of cis-(S,S,Sp,Sp)-bis[2-(2?-(4?-methylethyl)oxazolinyl)ferrocene-1-C,3?-N]palladium(II) (42% from X = Cl, 50% from X = Br). Selective monoprotodepalladation with HCl gave an S,Sp palladacycle containing a removable ferrocenyloxazoline ligand. Addition of PdCl2(MeCN)2 to mercuracycles in acetonitrile, themselves generated from Li-Hg transmetalation, followed by a brine wash gave (S,Sp)-di-mu-chlorobis[2-(2?-(4?-methylethyl)oxazolinyl)ferrocene-1-C,3?-N]dipalladium(II) as a single diastereoisomer in high yield. The alternative S,Rp diastereoisomer was obtained in the same way by use of a deuterium blocking group to reverse lithiation diastereoselectivity.
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Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method