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5-alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R5 have the meanings given in the claims and in the specification.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The base-free palladium-catalyzed borylation of aryl chlorides with diborons was achieved. The base-free conditions offered acceptable functional group compatibility. Based on experimental and computational studies, it was shown that smooth boryl transfer from the diborons to the arylpalladium chloride was promoted by strong interaction between the Lewis acidic boron and the chlorine atom on palladium.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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An efficient and stereoselective synthesis of pyrrolidine-, piperidine-, and azepane-type N-heterocycles is described by the intramolecular Pd(0)-catalysed cyclisation of amino allylic carbonates. The use of chiral ligands gave the corresponding heterocyclic derivatives having er values that were from moderate to good.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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9 – (Arylamino) – 9H – efficient production of aryl [to] carbazole. [Solution] a palladium compound, a phosphine compound, in the presence of a metal alkoxide, (1) represented by the formula […], carbazole derivative of the reaction. (Ar each independently a phenylene group or the like, the number of 1 – 4 carbon alkyl group substituted phenylene group or the like or may be; X is independently Cl, Br or I; 1 or 2 respectively and independently p q; R1 Are each independently a C1 a-6 alkyl group, a phenyl group, naphthyl group, pyridyl group or biphenylyl group; m is 1 or 2; n is 0 or 1; m + n=2)[Drawing] no (by machine translation)

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Substituted phenanthrene-9,10-diones in accord with structural diagram I, 1compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R1 at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH2, NO2, NH?CO?R2, CO?NH?R2, Ar, (CH2)nCH(COOH)R3 COR3 and NHCOCH2CH(COOH)NHR4, where R2, R3 and R4 are a selected from a variety of substituted or unsubstituted alkyl and aryl groupstand oligopeptides.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Fused (hetero)cyclic polymers are an important group of functional materials with unique electrochemical and photophysical properties. They are in great demand in high-tech applications such as organic electronics and advanced optical devices. Alkyne-based polymerizations have been found to be a powerful tool for the synthesis of fused (hetero)cyclic polymers. The fused (hetero)cyclic units can form in situ in the polymer backbones during the polymerizations. In this chapter, the progress in the synthesis of fused (hetero)cyclic polymers by alkyne-based polymerizations will be summarized, including the homopolymerizations of acetylenic monomers, stoichiometric polyannulations of internal diynes and aromatics, non-stoichiometric polyannulations of internal diynes and monofunctional aromatics, and multicomponent acetylenic polymerizations. Meanwhile, the properties and functionalities of the produced fused (hetero)cyclic polymers, such as thermal and morphological stability, light refraction and chromatic dispersion, photoluminescent properties, fluorescent chemosensor, external stimuli-responsive materials, etc., will also be discussed.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Mimicking the natural photosynthesis process, photocatalytic conversion of CO2 has been an ongoing hotspot of scientific research and technology development. A key aspect is the discovery of high potency catalysts for facilitating the multi-electron participated reactions. Herein we successfully demonstrate exfoliated nanosheets from a conductive 2D-MOF Ni3(HITP)2 as an efficient co-catalyst for CO2 reduction in a hybrid photocatalytic system under visible light illumination. By taking advantage of the high conductivity for charge transportation and highly accessible active sites for redox reactions, an excellent selectivity of 97% for deoxygenative CO2 reduction and a high CO yield rate of 3.45 × 104 mumol·g?1 h?1 were achieved with superior stability. This work provides essential insights into future design and development of more effective MOFs-based systems for catalytic CO2 utilization.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Herein we disclose a simple palladiumcatalyzed transformation for the methoxylation of aromatic chlorides with tetramethoxyborate salts. The procedure provides a new and efficient synthetic tool for the introduction of a methoxy group into aromatic systems. In addition, the reaction can be achieved using a wide range of aromatic and heteroaromatic chlorides, the cheapest class of halides.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method