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The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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Herein, borafluorene-conjugated polymers with a dibromoborafluorene monomer and various boronic acid ester comonomers are reported. By employing the Suzuki-Miyaura cross-coupling reaction, a series of copolymers was prepared with the boron atoms in tetracoordinated states. Based on comparison to the optical properties of gallafluorene copolymers, higher luminescence quantum yields were obtained from the synthesized borafluorene copolymers due to the weak spin-orbit interaction of boron compared to that of gallium. Additionally, the results from the electrochemical measurements indicated that the electron-withdrawing property of the boron atoms led to stabilization of the lowest unoccupied molecular orbitals (LUMOs) of the borafluorene copolymers. In the X-ray diffraction profiles, significant peaks originating from pi-pi stacking and assembly of the side chains were observed. The borafluorene copolymers were more crystalline than the gallafluorene polymers.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Extracurricular laboratory:new discovery of 52409-22-0

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An unexpected ring opening of 3-aminobenzofurans promoted by NaOtBu in hot toluene, leading to a variety of alpha-ketoimines, is described. In the presence of 3-iodobenzofurans, NaOtBu mediates the 3-aminobenzofurans ring opening via a possible radical pathway without the help of any external radical sources.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Final Thoughts on Chemistry for 52409-22-0

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Polymer light-emitting diodes (PLEDs) based on thermally activated delayed fluorescence (TADF) emitters show great potential in developing high-efficiency solution-processed light-emitting devices without the use of noble metal complexes. However, a key challenge for the development of TADF-PLEDs so far is the lack of polymer hosts with suitable triplet energy levels (ETs) and good carrier transport capability. Here, we report the design, synthesis, and electroluminescent properties of a novel series of bipolar poly(arylene phosphine oxide) hosts based on electron-transporting arylphosphine oxide and hole-transporting carbazole units, which show widely tunable ETs in the range of 2.20-3.01 eV by finely tuning the conjugation extent of the polymer backbone. The tunable ETs make these polymers a universal host family for all of the blue, green, and red TADF emitters. TADF-PLEDs based on these polymer hosts show promising device efficiency with external quantum efficiencies up to 15.8, 17.1, and 10.1% for blue, green, and red emissions, respectively, which are among the highest efficiencies for TADF-PLEDs. These results open an avenue for the development of TADF-PLEDs with high efficiency and full-color emission in the future.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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The invention provides an antimycobacterial 6-aryl-9-(m- or p-substituted-benzyl) purine and purine analog compounds.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

More research is needed about Pd2(DBA)3

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Aromatic high-performance triphenylamine-based polyfluorenes (PTPAFs) have been successfully constructed by palladium-catalyzed polycondensation reaction. The chemical structures of the resulting PTPAFs are confirmed by means of Fourier-transform infrared spectroscopy and nuclear magnetic resonance, and the testing results showed a good agreement with the proposed structures. The resulted polymers show excellent solubility, high thermal stability with the decomposition temperatures (Td5%) over 320 C and the glass transition temperatures (Tg) over 305 C. The PTPAF1 and the PTPAF2 exhibit the enhanced high occupied molecular orbital (HOMO) energy levels (? 3.93 eV, ? 4.00 eV, respectively) and the depressed low unoccupied molecular orbital (LUMO) energy levels (? 0.99 eV, ? 1.41 eV, respectively). Owing to their special structures, PTPAFs showed encouraging photonic luminescence and good electroactivity and could be used as a potential light source in the blue region.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The Absolute Best Science Experiment for Pd2(DBA)3

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A synthesis of vicinal diamines via in situ aminal formation and carboamination of allyl amines is reported. Employing highly electron-poor trifluoromethyl aldimines in their stable hemiaminal form was key to enable both a fast and complete aminal formation as well as the palladium-catalyzed carboamination step. The conditions developed allow the introduction of a wide variety of alkynyl, vinyl, aryl, and hetereoaryl groups with complete regioselectivity and high diastereoselectivity. The reaction exhibits a high functional-group tolerance. Importantly, either nitrogen atom of the imidazolidine products can be selectively deprotected, while removal of the aminal tether can be achieved in a single step under mild conditions to reveal the free diamine. We expect that this work will promote the further use of mixed aminal tethers in organic synthesis.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A process for the carbonylation of an ethylenically unsaturated compound comprising the step of reacting said compound with carbon monoxide in the presence of a co-5 reactant having a mobile hydrogen atom and a catalyst system is described. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a suitable compound thereof; (b) a ligand of general formula (I): and c) optionally, a source of anions. The invention is characterised in that the catalyst system includes an enhancer compound comprising an aromatic ring or ring system substituted by at least one hydroxyl group wherein the hydroxyl group pKa at 25 C. is greater than 3.0 and less than 9.1, the said enhancer compound excluding 3-quinolinol. Catalyst systems for use with the enhancer compound are described as are a method of increasing the efficacy of a catalyst system for the carbonylation of ethylenically unsaturated compounds and a method of increasing the rate of carbonylation of an ethylenically unsaturated compound comprising the step of adding such a compound to the reaction.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

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A palladium bromide and copper(I) bromide co-catalyzed reaction of 4-tosyloxy coumarin with benzo[d]oxazole/oxazole/benzo[d]thiazole via C-H activation is described, which generates 4-substituted coumarins in moderate to good yields. 4-Tosyloxy quinolin-2(1H)-one and 2H-pyran-2-one could be applied in this transformation as well.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Simple exploration of Pd2(DBA)3

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The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method