Category: 27828-71-3

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zeitschrift fuer Anorganische und Allgemeine Chemie called Supramolecular Chemistry Based on Gallium-Gallium Single Bonds – Formation of Large Heterocycles and Cages with up to Twelve Gallium Atoms, Author is Uhl, Werner; Stefaniak, Christina; Voss, Matthias; Layh, Marcus; Rogel, Friedhelm; Koesters, Jutta, which mentions a compound: 27828-71-3, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3, Related Products of 27828-71-3.

The tetraalkyldigallium(II) compound R2Ga-GaR2 (1) [R = CH(SiMe3)2] reacted with amino and hydroxo functionalized carboxylic acids by retention of the Ga-Ga bond and release of CH2(SiMe3)2. New heterocyclic or cage-like compounds were formed with three, two, or six Ga-Ga bonds in a single mol. The latter dodecagallium compounds encapsulated THF or dioxane mols. in their mol. cavities (carcerands), the other compounds have up to six THF mols. coordinated by N-H···O hydrogen bonds.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 27828-71-3, is researched, Molecular C6H5NO3, about Synthesis, psychopharmacological and antihypoxic activity of β-substituted pyridinecarboxylic acids, the main research direction is pyridinecarboxylate preparation antihypoxic psychopharmacol structure.Category: catalyst-palladium.

Several title compounds [I; R1 = H, OH; R2 = H, OH, Br, CO2Et; R3 = H, OH, CO2H, CO2Na; R4 = H, CONH2, CO2H, NHCOPh, NHCOC6H2(MeO)2] were prepared and tested with other I for toxicity and for antihypoxic, anticonvulsant, and behavioral effects in mice and rats. The pharmacol. most active I were 5-hydroxynicotinate derivatives which, depending on the nature and position of the other substituents, exhibited sedative, anticonvulsant, or antihypoxic activity, or increased phys. endurance. Structure-activity relations are discussed.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27828-71-3, is researched, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3Journal, Article, Research Support, Non-U.S. Gov’t, Cell Chemical Biology called A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast, Author is Li, Yi; Tian, Caiping; Liu, Keke; Zhou, Ying; Yang, Jing; Zou, Peng, the main research direction is Saccharomyces proteomics APEX2 alkyne phenol; APEX2; RNA; bioorthogonal reaction; mass spectrometry; mitochondria; proteomics; proximity labeling; spatial transcriptomics; yeast.COA of Formula: C6H5NO3.

The engineered ascorbate peroxidase (APEX) is a powerful tool for the proximity-dependent labeling of proteins and RNAs in live cells. Although widely use in mammalian cells, APEX applications in microorganisms have been hampered by the poor labeling efficiency of its biotin-phenol (BP) substrate. In this study, we sought to address this challenge by designing and screening a panel of alkyne-functionalized substrates. Our best probe, Alk-Ph, substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than BP. Through a combination of protein-centric and peptide-centric chemoproteomic experiments, we have identified 165 proteins with a specificity of 94% in the yeast mitochondrial matrix. In addition, we have demonstrated that Alk-Ph is useful for proximity-dependent RNA labeling in yeast, thus expanding the scope of APEX-seq. We envision that this improved APEX-labeling strategy would set the stage for the large-scale mapping of spatial proteome and transcriptome in yeast.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27828-71-3, is researched, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3Conference, Metab. Eff. Nicotinic Acid Its Deriv., Proc. Workshop called Effect of nicotinic acid and ring-substituted analogs on the in vivo biosynthesis of cholesterol and fatty acids in rat liver, Author is Miller, O. Neal; Gutierrez, M.; Sullivan, Ann; Hamilton, J. G., the main research direction is nicotinate analog lipolysis; hydroxynicotinate lipolysis; cholesterol synthesis nicotinate derivative.Recommanded Product: 27828-71-3.

Of 24 nicotinic acid analogs tested, 2-hydroxynicotinate [609-71-2], 2-methylnicotinate [3222-56-8], and 5-chloronicotinate [22620-27-5] had greater in vivo fatty acid and cholesterol biosynthesis inhibitory activity than nicotinic acid [59-67-6] in rats.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27828-71-3, is researched, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3Conference, Metab. Eff. Nicotinic Acid Its Deriv., Proc. Workshop called Comparison of the effect of nicotinic acid derivatives on in vitro lipolysis and in vivo lipid lowering, Author is Dalton, Colin; Quinn, Janie B.; Crowley, H. J.; Miller, O. Neal, the main research direction is nicotinate lipolysis; fluoronicotinate antilipolysis; cholesterol nicotinate; fatty acid serum nicotinate.Name: 5-Hydroxynicotinic acid.

Nicotinic acid (I) [59-67-6] showed greater in vitro antilipolytic against theophylline [58-55-9]-induced lipolysis in rat isolated fat cells than 20 I derivatives, but some antilipolytic activity was maintained in 8 substituted I derivatives such as 5-fluoronicotinic acid [402-66-4], 5-methylnicotinic acid [3222-49-9], and 5-aminonicotinic acid [24242-19-1]. Compounds active in vitro reduced serum free fatty acids and triglycerides in the fasted rat, and 5-fluoronicotinic acid was 3-4 times more active in this respect than I. I and 5-fluoronicotinic acid lowered serum cholesterol [57-88-5] 24 hr after injection in the fasted rat, and were effective in reducing norepinephrine [51-41-2]-elevated serum free fatty acids and glycerol [56-81-5] levels in the dog, with 5-fluoronicotinic acid having the longer duration of action.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Category: catalyst-palladium. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Crystal structure of poly[bis(μ2-5-hydroxynicotinato-κ2 N:O 3)zinc]. Author is Wang, Wen-Bing; Xu, Shan-Shan; Chen, Hong-Ji.

The title coordination polymer, [Zn(C6H4NO3)2]n, was prepared under hydrothermal conditions by the reaction of zinc nitrate with 5-hydroxynicotinic acid in the presence of malonic acid. In the structure, the ZnII ion is coordinated by two carboxylate O atoms and two pyridine N atoms of four 5-hydroxynicotinate ligands in a distorted tetrahedral coordination environment. The μ2-bridging mode of each anion leads to the formation of a three-dimensional framework structure. Intermol. hydrogen bonds between the hydroxy groups of one anion and the non-coordinating carboxylate O atoms of neighboring anions consolidate the crystal packing.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27828-71-3, is researched, SMILESS is O=C(O)C1=CN=CC(O)=C1, Molecular C6H5NO3Journal, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya called Study of the kinetics of isotopic exchange of hydrogen in 5-hydroxynicotinic acid, Author is Lezina, V. P.; Stolyarova, L. G.; Shirokova, L. V.; Smirnov, L. D., the main research direction is hydroxynicotinic acid exchange kinetics; nicotinic acid hydroxy exchange kinetics; deuterium exchange hydroxynicotinic acid.Quality Control of 5-Hydroxynicotinic acid.

Kinetic studies of H-D exchange of 5-hydroxynicotinic acid (I) at 160° and pD 6.5-10.5 showed that only the 6-position of the ring underwent exchange. The rate constant for the step involving the dianion of I was determined

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 27828-71-3, is researched, Molecular C6H5NO3, about Green Conversion of CO2 and Propargylamines Triggered by Triply Synergistic Catalytic Effects in Metal-Organic Frameworks, the main research direction is metal organic framework green catalyst carbon dioxide propargylamine cyclization; CO2; MOFs; flue gas; green catalysis; synergism.Reference of 5-Hydroxynicotinic acid.

Cyclization of propargylamines with CO2 to obtain 2-oxazolidone heterocyclic compounds is an essential reaction in industry but it is usually catalyzed by noble-metal catalysts with organic bases as co-catalysts under harsh conditions. We have synthesized a unique CuI/CuII mixed valence copper-based framework {[(CuI6I5)Cu3IIL6(DMA)3](NO3)·9DMA}n (1) with good solvent and thermal stability, as well as a high d. of uncoordinated amino groups evenly distributed in the large nanoscopic channels. Catalytic experiments show that 1 can effectively catalyze the reaction of propargylamines with CO2, and the yield can reach 99 %. The turnover frequency (TOF) reaches a record value of 230 h-1, which is much higher than that of reported noble-metal catalysts. Importantly, this is the first report of heterogeneously catalyzed green conversion of propargylamines with CO2 without solvents and co-catalysts under low temperature and atm. pressure. A mechanistic study reveals that a triply synergistic catalytic effect between CuI/CuII and uncoordinated amino groups promotes highly efficient and green conversion of CO2. Furthermore, 1 directly catalyzes this reaction with high efficiency when using simulated flue gas as a CO2 source.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

Formula: C6H5NO3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Hydroxynicotinic acid, is researched, Molecular C6H5NO3, CAS is 27828-71-3, about Aromaticity and stability going in opposite directions: An energetic, structural, magnetic and electronic study of aminopyrimidines. Author is Ribeiro da Silva, Manuel A. V.; Galvao, Tiago L. P.; Rocha, Ines M.; Santos, Ana Filipa L. O. M..

The relation between mol. energetics and aromaticity was investigated for the interaction between the amino functional group and the nitrogen atoms of the pyridine and pyrimidine rings, using exptl. thermodn. techniques and computational geometries, enthalpies, chem. shifts, at. charges and the Quantum Theory of Atoms in Mols. 2,4-diaminopyrimidine and 2,4,6-triaminopyrimidine were studied by static bomb combustion calorimetry and Knudsen effusion technique. The derived gaseous-phase enthalpies of formation together with the enthalpies of formation of the three isomers of aminopyridine reported in the literature, were compared with the calculated computationally ones and extended to other diamino- and triaminopyrimidine isomers using the MP2/6-311++G(d,p) level of theory. The results were analyzed in terms of enthalpy of interaction between substituents and, due to the absence of meaningful stereochem. hindrance, strong inductive effects, or intramol. hydrogen bonds according to QTAIM results, the resonance electron delocalization plays an almost exclusive role in the very exothermic enthalpies obtained. Therefore, this enthalpy of interaction was used as an exptl. energetic measure of resonance effects and analyzed in terms of aromaticity. It was found that more conjugation between substituents means less aromaticity according to the magnetic (NICS) and electronic (Shannon) criteria, but more aromaticity according to the geometric (HOMA) criterion.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Hydroxynicotinic acid( cas:27828-71-3 ) is researched.Synthetic Route of C6H5NO3.Xu, Mingshuo; Wang, Yu; Yang, Feipu; Wu, Chunhui; Wang, Zhen; Ye, Bin; Jiang, Xiangrui; Zhao, Qingjie; Li, Jianfeng; Liu, Yongjian; Zhang, Junchi; Tian, Guanghui; He, Yang; Shen, Jingshan; Jiang, Hualiang published the article 《Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs》 about this compound( cas:27828-71-3 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: pyridinecarboxamide preparation multireceptor antipsychotic; 5-HT(1A) receptor; Antipsychotic; Multi-receptor; PCP-induced hyperlocomotion; Pyridinecarboxamide. Let’s learn more about this compound (cas:27828-71-3).

In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives The most promising compound I not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, I exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.

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Reference:
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method