Reference of 52409-22-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 52409-22-0, Pd2(DBA)3, introducing its new discovery.
Single-Flask Multicomponent Palladium-Catalyzed alpha,gamma-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds
A three-component palladium-catalyzed reaction sequence has been developed in which gamma-substituted alpha,beta-unsaturated products are obtained in a single flask by an alpha-alkenylation with either a subsequent gamma-alkenylation or gamma-arylation of a ketone enolate. Coupling of a variety of electronically and structurally different components was achieved in the presence of a Pd/Q-Phos catalyst (2mol %), usually at 22 C with yields of up to 85 %. Most importantly, access to these products is obtained in one simple operation in place of employing multiple reactions. Building bridges: The title reaction was developed for the construction of gamma-substituted alpha,beta-unsaturated ketones under mild reaction conditions. High levels of regioselectivity and control of incorporation of reaction components are exhibited, thus producing complex scaffolds in a single-flask procedure. dba=dibenzylideneacetone, THF=tetrahydrofuran, Q-Phos=1-di-tert-butylphosphino-1?,2?,3?,4?,5?-pentaphenylferrocene.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 52409-22-0. In my other articles, you can also check out more blogs about 52409-22-0
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method