Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 52409-22-0. Introducing a new discovery about 52409-22-0, Name is Pd2(DBA)3
Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions
Application of Buchwald-Hartwig catalysis for development of biologically relevant arylspirodiamine compounds is reported. This synthetic methodology requires no inert atmosphere and affords yields up to 93% in just 20?min. Linear and sterically hindered angular spirodiamines in salt and free-base form are coupled with electron-rich and -withdrawing aryl chlorides, demonstrating a broad scope and applicability of this protocol.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 52409-22-0, you can also check out more blogs about52409-22-0
Reference£º
Chapter 1 An introduction to palladium catalysis,
Palladium/carbon catalyst regeneration and mechanical application method